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. 2016 Jul;57(7):1144–1154. doi: 10.1194/jlr.M064709

Fig. 3.

Fig. 3.

Cyp7a1−/− mice fed Western diet have reduced and altered bile acid composition. A (upper left panel): Bile acid pool size is significantly reduced in Western diet-fed Cyp7a1−/− mice compared with WT mice (n = 6). GB, gallbladder; Int, intestine. A (upper right panel): Bile acid synthesis and nuclear receptor gene expression in WT and Cyp7a1−/− mice maintained on Western diet. A (lower panel): Bile acid composition, expressed as a percentage of total detected bile acids, in Western diet-fed WT and Cyp7a1−/− mice. B (upper left panel): Bile acid pool size in Western diet-fed mice supplemented with 0.03% CA. B (upper right panel): Bile acid synthesis and nuclear receptor gene expression in WT and Cyp7a1−/− mice maintained on Western diet + 0.03% CA. B (lower panel): Bile acid composition in Western diet + CA-fed WT and Cyp7a1−/− mice. WT (white bar), Cyp7a1−/− (black bar). Data were analyzed by Student’s t-test; *P < 0.05.