Fig. 4.

Cyp7a1^−/− mice fed Western diet maintain improved glucose tolerance, which is reversed with CA supplementation. A: Cyp7a1^−/− mice fed Western diet have significantly improved response to glucose (upper panel) but not insulin (lower panel), though the baseline 5 h fasting blood glucose levels were significantly reduced in Cyp7a1^−/− mice (n = 6–7). GTT, glucose tolerance test; ITT, insulin tolerance test. B: Following feeding a Western diet supplemented with 0.03% CA for 10 weeks, glucose (upper panel) and insulin (lower panel) tolerance was worsened in Cyp7a1^−/− mice. WT (white triangle or bar), Cyp7a1^−/− (black triangle or bar), WT + CA (white diamond), Cyp7a1^−/− + CA (black diamond). Data were analyzed by Student’s t-test; *P < 0.05.