Fig 1. Contribution of S. aureus coa, vwb and clfA to formation of rabbit abscesses.

(A) Average abscess volume for rabbits infected subcutaneously with S. aureus Newman wild-type (WT) or isogenic mutant strains as indicated. The volume of 10 abscesses per bacterial strain was measured daily following inoculation. (B) Individual abscesses plotted for selected days are depicted in panel A. (C) A separate set of 2 animals (4 abscesses/strain) was used to determine S. aureus CFU per abscess on day 2 post-infection and (D) the volume of rabbit abscesses. Each symbol represents a data point obtained from a single abscess. P values were calculated using a one-way ANOVA and Dunnett’s post-test.