Table 1.
In Vitro Data against Malaria and Leishmania
| compound |
P. falciparum (D6 clone)
|
P. falciparum (W2 clone)
|
cytotoxicity (Vero)
|
L. donovani
|
|
|---|---|---|---|---|---|
| IC50 (ng/mL) | IC50 (ng/mL) | TC50 (μg/mL) | IC50 (μg/mL) | IC90 (μg/mL) | |
| 1 | 4.2 | 5.0 | 680 | 0.9 | 1.8 |
| 2 | 6.0 | 8.0 | 1100 | 6.2 | 11 |
| 3 | 9.6 | 30 | 370 | 3.4 | 7.0 |
| 4 | 1300 | 1200 | NCa | 16 | 35 |
| 5 | 37 | 47 | 980 | 5 | 24 |
| chloroquine | 14 | 155 | –b | – | – |
| artemisinin | 4.3 | 4.4 | – | – | – |
| pentamidine | – | – | – | 2.6 | 6.9 |
| amphotericin B | – | – | – | 0.4 | 0.36 |
a
NC, no cytotoxicity (concentration: 4.76 μg/mL).
b
–, not tested.