Table 3.
In Vitro Antimicrobial Activitiesa
| compound |
C. albicans (μg/mL)
|
C. neoformans (μg/mL)
|
MRSA (μg/mL)
|
M. intracellulare (μg/mL)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | MIC | MFC | IC50 | MIC | MFC | IC50 | MIC | MFC | IC50 | MIC | MBC | |
| 1 | 2.0 | –b | – | 3.0 | 10 | – | 0.7 | – | – | 0.35 | 0.63 | – |
| 2 | 10 | 20 | – | 3.0 | 5.0 | – | 6.5 | – | – | 0.25 | 0.31 | – |
| 3 | 1.5 | 2.5 | 5.0 | 1.5 | 2.5 | 5.0 | 0.45 | 0.5 | 20 | 0.1 | 0.16 | >20 |
| 4 | >20 | – | – | >20 | – | – | 2.0 | 5.0 | >20 | 4.5 | 10 | >20 |
| 5 | 3.0 | 10 | >20 | 2.0 | 5.0 | 5.0 | 0.55 | >20 | >20 | 0.15 | 0.63 | 20 |
| amphotericin B | 0.1 | 0.63 | 1.25 | 1.00 | 2.5 | 2.5 | – | – | – | – | – | – |
| ciprofloxacin | – | – | – | – | – | – | 0.06 | 0.25 | 1.0 | 0.25 | 0.5 | >20 |
a
Amphotericin B and ciprofloxacin are used as positive antifungal and antibacterial controls, respectively. The IC50 is the concentration that affords 50% inhibition of growth. MIC (minimum inhibitory concentration) is the lowest test concentration that yields detectable growth. MFC/MBC (minimum fungicidal/bactericidal concentration) is the lowest test concentration that kills 100% of the organism.
b
– = not tested.