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. 2016 Jun 23;12(6):e1005692. doi: 10.1371/journal.ppat.1005692

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© 2016 Zarnitsyna et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — We describe antigenic drift by changing only epitope Y on the head of HA between the two virus strains. Antibody to X generated in response to a previously experienced strain sterically hinders efficient stimulation of B cells specific for the new epitope Y.