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. 2016 Mar;7(3-4):73–85. doi: 10.18632/genesandcancer.100

Figure 1. MCF7-ARO cells are sensitive to single agent and combination taselilsib and letrozole.

Figure 1

(A) Cell potency of taselisib and letrozole was determined in a 96-hour viability assay. (B) Taselisib combines well with letrozole in MCF7-ARO cells. The effect on viability of taselisib and letrozole as single agents is shown in the black and red lines, respectively. The combination effect of the two drugs is indicated with the blue line. (C) Increased growth arrest and apoptosis when taselisib and letrozole are combined. Immunoblots from MCF7-ARO samples treated for 24 hours with 0.4 μM taselisib and/or 0.6 μM letrozole. (D) Taselisib and letrozole independently influence the expression of well-known ER target genes. Treatments are for 0.4 hrs with 0.6 μM taselisib and/or 0.1μM letrozole. Dotted lines for all viability data are indicative of CellTiterGlo counts at the beginning of drug treatment. Error bars indicate standard deviation around the mean.