Skip to main content
. 2016 Jun 23;12(6):e1005624. doi: 10.1371/journal.ppat.1005624

Fig 2. Multifaceted actions of IL-26 in antiviral, antimicrobial, and autoimmune responses.

Fig 2

Upon activation, various immune cells secrete IL-26. IL-26 exerts antiviral and antimicrobial actions through dual action by (A) direct killing of bacteria by forming membrane pores and (B) by priming immune cells, such as neutrophils, NK cells, and plasmacytoid dendritic cells (pDCs). Other Th17 cell-derived molecules might act in synergy with IL-26 to enhance this direct killing of bacteria. (C) IL-26 response requires tight regulation as increased expression of IL-26 has been reported in several autoimmune and inflammatory diseases, including Crohn’s disease and rheumatoid arthritis (RA). This scheme was drawn in part by using pictures from Servier Medical Art.