Fig 6. Transcriptional factor network of the liver response at 12 h post-intramammary infection challenge with E. coli.

Reported is the cross-talk among the transcription factors (TF) in bovine liver uncovered to be either activated or inhibited by Ingenuity Pathway Analysis (IPA; from Fig 3). The potential up-stream endogenous chemicals, growth factors, and cytokines affecting the activation or inhibition of the TF are estimated by IPA. The TF network included all the TF and ligand-dependent nuclear receptors. The network allows visualizing the interaction among TF, the overall estimated activation or inhibition, the up- or down-regulation, the up-stream activators or inhibitors, and the enriched functions (light blue shade) or pathways (yellow shade) with the larger number of differentially expressed genes.