Table 3. ROC analysis to predict the diagnostic impact of the miRNA and mRNA target expression.

Marker	AUC (95% CI)
	between N and ccRCC	between ccRCC-M0 and ccRCC-M1
HS6ST2	0.974 (0.941–1.000)****	0.697 (0.492–0.902)ns
LOX	0.849 (0.725–0.973)****	0.811 (0.644–0.979)**
miR-141	0.912 (0.815–1.000)****	0.539 (0.315–0.763)ns
miR-145	0.711 (0.565–0.857)**	0.694 (0.492–0.897)ns

AUC = area under the curve; N = non-malignant renal tissue from ccRCC patients; ccRCC = malignant renal tissue from ccRCC patients; ccRCC-M0 = malignant renal tissue from ccRCC patients without metastasis; ccRCC-M1 = malignant renal tissue from ccRCC patients with metastasis

** p < 0.01

**** p < 0.0001; ns = not significant