Table 3. Sensitivity Analysis to Examine Sources of Heterogeneity.
| Missed | Incident | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
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| Subgroup analysis | No. of studies | Total cases | n | Pooled weighted proportion | 95% CI | n | Pooled weighted proportion | 95% CI | Heterogeneity I2,% | Heterogeneity between groups, P valuea |
| Study quality | ||||||||||
| EAC | .63 | |||||||||
| High | 2 | 7 | 0 | 11.7 | 1.6–51.8 | 7 | 88.3 | 48.2–98.4 | 0 | |
| Medium | 17 | 777 | 313 | 27.7 | 16.8–42.2 | 464 | 72.3 | 57.8–83.2 | 81 | |
| Low | 5 | 36 | 7 | 27.1 | 14.5–45.0 | 29 | 72.9 | 55.0–85.5 | 0 | |
| HGD-EAC | <.01 | |||||||||
| High | 3 | 48 | 3 | 8.2 | 3.1–19.9 | 45 | 91.8 | 80.1–96.9 | 0 | |
| Medium | 17 | 1453 | 635 | 30.2 | 20.4–42.3 | 818 | 69.8 | 57.7–79.6 | 90 | |
| Low | 0 | — | — | — | — | — | — | — | — | |
| Study design | ||||||||||
| EAC | .26 | |||||||||
| Population-based | 3 | 710 | 300 | 40.8 | 16.9–70.1 | 410 | 59.2 | 29.9–83.1 | 97 | |
| Other | 21 | 110 | 20 | 24.7 | 17.3–33.9 | 90 | 75.3 | 66.1–82.7 | 0 | |
| HGD-EAC | .04 | |||||||||
| Population-based | 4 | 1330 | 607 | 42.5 | 24.3–62.9 | 723 | 57.5 | 37.1–75.7 | 4 | |
| Other | 16 | 171 | 31 | 21.7 | 15.5–29.5 | 140 | 78.3 | 70.5–84.5 | 98 | |
| Study setting | ||||||||||
| EAC | .34 | |||||||||
| Multicenter | 6 | 731 | 305 | 34.6 | 17.4–57.2 | 426 | 65.4 | 42.8–82.6 | 92 | |
| Single-center | 18 | 89 | 15 | 24.0 | 16.0–34.3 | 74 | 76.0 | 65.7–84.0 | 0 | |
| HGD-EAC | .28 | |||||||||
| Multicenter | 8 | 1428 | 625 | 31.3 | 19.1–46.9 | 803 | 68.7 | 53.1–80.9 | 95 | |
| Single-center | 12 | 73 | 13 | 22.0 | 13.5–33.6 | 60 | 78.0 | 66.4–86.5 | 0 | |
| Study regionb | ||||||||||
| EAC | .21 | |||||||||
| Europe | 16 | 782 | 316 | 28.9 | 17.7–43.3 | 466 | 71.1 | 56.7–82.3 | 81 | |
| United States | 7 | 37 | 4 | 16.8 | 7.6–33.2 | 33 | 83.2 | 66.8–92.4 | 0 | |
| HGD-EAC | .47 | |||||||||
| Europe | 15 | 1439 | 625 | 28.5 | 18.4–41.4 | 814 | 71.5 | 58.6–81.6 | 91 | |
| United States | 4 | 61 | 13 | 20.7 | 8.8–41.5 | 48 | 79.3 | 58.5–91.2 | 44 | |
| Publication date | ||||||||||
| EAC | .27 | |||||||||
| Before 2000 | 6 | 19 | 1 | 14.1 | 4.6–35.9 | 18 | 85.9 | 64.1–95.4 | 0 | |
| 2000–2009 | 13 | 81 | 16 | 26.2 | 17.5–37.4 | 65 | 73.8 | 62.6–82.5 | 0 | |
| After 2010 | 5 | 720 | 303 | 38.6 | 17.9–64.4 | 417 | 61.4 | 35.6–82.1 | 95 | |
| HGD-EAC | .36 | |||||||||
| Before 2000 | 4 | 17 | 1 | 12.2 | 3.0–38.2 | 16 | 87.8 | 61.8–97.0 | 0 | |
| 2000–2009 | 8 | 67 | 17 | 28.7 | 19.0–40.9 | 50 | 71.3 | 59.1–81.0 | 0 | |
| After 2010 | 8 | 1417 | 620 | 31.4 | 18.8–47.5 | 797 | 68.6 | 52.6–81.2 | 95 | |
| Duration of follow-up, y | ||||||||||
| EAC | .32 | |||||||||
| 3–5 | 14 | 581 | 184 | 32.5 | 28.8–36.4 | 397 | 67.5 | 63.6–71.2 | 0 | |
| 5–8 | 7 | 229 | 136 | 26.8 | 9.9–55.0 | 93 | 73.2 | 45.0–90.1 | 70 | |
| ≥8 | 3 | 10 | 0 | 11.8 | 2.4–42.5 | 10 | 88.2 | 57.5–97.6 | 0 | |
| HGD-EAC | <.01 | |||||||||
| 3–5 | 11 | 813 | 238 | 22.5 | 14.8–32.7 | 575 | 77.5 | 67.2–85.2 | 52 | |
| 5–8 | 6 | 666 | 398 | 52.3 | 40.0–64.2 | 268 | 47.7 | 35.8–60.0 | 71 | |
| ≥8 | 3 | 22 | 2 | 12.8 | 4.2–33.0 | 20 | 87.2 | 67.0–95.8 | 0 | |
a
P ≤ .10, explains source of heterogeneity between groups and appear in bold.
b
One Australian study was excluded.34