Table 3. Multivariate Repeat Measure Mixed Linear Model Regression analyses for the effects of disease status and MAPT transcript levels.
| MAPT | MAPT-AS1 | |||
|---|---|---|---|---|
| Predictor a | t-Statistic | p valueb | t-Statistic | p valueb |
| Disease | -1.456 | 0.179 | - | - |
| MAPT1-AS1 | 5.656 | 2.57E-04 | - | - |
| Disease * MAPT-AS1 | -4.286 | 0.001 | - | - |
| Disease | -2.365 | 0.027 | 0.825 | 0.415 |
| DNMT1 | 4.476 | 0.001 | 0.849 | 0.407 |
| Disease * DNMT1 | -2.991 | 0.006 | -1.014 | 0.318 |
| Disease | -0.551 | 0.583 | 0.696 | 0.49 |
| DNMT3A | 1.512 | 0.135 | 2.62 | 0.013 |
| Disease * DNMT3A | -0.941 | 0.35 | -0.875 | 0.386 |
| Disease | -1.121 | 0.311 | -0.201 | 0.841 |
| DNMT3B | -2.407 | 0.062 | 0.066 | 0.948 |
| Disease * DNMT3B | -0.791 | 0.463 | -0.995 | 0.302 |
a For each gene of interest, demographic covariates were included in the multivariate regression analyses if they were significantly associated in the initial univariate analysis (Table 2). For MAPT and MAPT-AS1: Tissue pH; MAPT and DNMT1: Tissue pH; MAPT and DNMT3A: Tissue PH; MAPT and DNMT3B: Tissue pH and Gender. For MAPT-AS1 and DNMT3B: Gender.
b p values that survived correction for multiple testing are indicated in bold.