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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 May 26;36(7):1434–1447. doi: 10.1161/ATVBAHA.116.307573

Figure 1. RNA-seq differential AS analysis of HMDMs, iPSDMs, and PBMCs.

Figure 1

A, Overview of cell types studied. PBMCs were isolated from human donors and were differentiated into primary M0-HMDMs, reprogrammed into iPSCs with subsequent macrophage differentiation, or stimulated with LPS in vivo in an evoked endotoxemia experiment. M0-HMDMs and M0-iPSDMs were then activated to M1 or M2 states. B, Distribution of differential AS and alternative promoter events for each experimental condition and cell type. C, Venn diagrams of single cassette exon events for each type of cell stimulation shows distinct differential AS patterns for each condition. HMDMs = human monocyte derived macrophages; iPSDMs = induced pluripotent stem cell derived macrophages; PBMCs = peripheral blood mononuclear cells; AS = alternative splicing.