. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 May 26;36(7):1434–1447. doi: 10.1161/ATVBAHA.116.307573

Table 1. Top Enriched Pathways Associated with Differential Alternative Splicing Events.

Pathway	-log(P-value)
*M0-HMDM vs M1-HMDM*
Apoptosis Signaling	6.03
PI3K/AKT Signaling	4.15
mTOR Signaling	4.08
CDK5 Signaling	4.02
ERK/MAPK Signaling	3.94
NF-κB Signaling	2.04
*M0-HMDM vs M2-HMDM*
TWEAK Signaling	3.47
TNFR1 Signaling	3.03
PEDF / PPARγ Signaling	2.54
Interferon Signaling	2.11
PKR in inflammation	1.95
Glycogen Biosynthesis	1.70
*Pre- vs Post-LPS PBMCs*
IGF-1 Signaling	2.10
Lipoate Salvage and Modification	1.74
Cell Cycle Checkpoint Regulation	1.57
Hypoxia Signaling in the Cardiovascular System	1.57
Insulin Receptor Signaling	1.51
Nitric Oxide Signaling in the Cardiovascular System	1.51

Pathways identified by Ingenuity Pathway Analysis for genes that are differentially spliced in each experimental condition. LPS = lipopolysaccharide, PBMC = peripheral blood mononuclear cells, HMDM =human monocyte derived macrophage.