Table 3. Cardiometabolic Trait-Associated Genetic Variants in Differentially Spliced M1-HMDM Genes.
| SNP | Chr | Position | Gene | Effect Allele | Trait | Consortium | Unadjusted P | FDR –Adjusted P | Bonferroni-Adjusted P |
|---|---|---|---|---|---|---|---|---|---|
| rs12765320 | 10 | 45930805 | ALOX5 | T | HDL | GLGC | 2.8E-07 | 1.7E-04 | 2.8E-04 |
| rs12325278 | 16 | 28848818 | ATXN2L | G | BMI | GIANT | 3.5E-10 | 8.1E-07 | 2.8E-07 |
| rs12448482 | 16 | 28838073 | ATXN2L | G | BMI | GIANT | 8.8E-08 | 7.3E-05 | 7.1E-05 |
| rs10838663 | 11 | 47184971 | C11orf49 | T | HDL | GLGC | 2.8E-16 | 2.1E-12 | 2.8E-13 |
| rs2291443 | 11 | 47179861 | C11orf49 | A | HDL | GLGC | 3.1E-07 | 1.7E-04 | 3.0E-04 |
| rs7117404 | 11 | 47127153 | C11orf49 | A | HDL | GLGC | 3.5E-05 | 2.9E-03 | 3.4E-02 |
| rs2156499 | 18 | 47007234 | C18orf32 | A | HDL | GLGC | 2.5E-08 | 2.0E-05 | 2.5E-05 |
| rs3094379 | 9 | 136334910 | CACFD1 | T | CAD | CARDIoGRAM | 2.6E-05 | 1.5E-02 | 2.2E-02 |
| rs739468 | 9 | 136326248 | CACFD1 | T | LDL, TC | GLGC | 5.5E-06 | 8.8E-03 | 5.5E-03 |
| rs11086985 | 20 | 44532255 | CTSA | A | HDL | GLGC | 6.6E-08 | 4.4E-05 | 6.5E-05 |
| rs3817731 | 20 | 44518843 | CTSA | A | HDL | GLGC | 4.8E-06 | 7.8E-03 | 4.7E-03 |
| rs10982200 | 9 | 117168551 | DFNB31 | A | HDL | GLGC | 4.8E-05 | 3.7E-03 | 4.7E-02 |
| rs9319588 | 16 | 30930983 | FBXL19 | T | TG | GLGC | 7.9E-06 | 1.7E-02 | 7.7E-03 |
| rs6781942* | 3 | 119758049 | GSK3B | A | TC | GLGC | 3.8E-05 | 2.2E-03 | 2.4E-02 |
| rs2306556* | 4 | 156638573 | GUCY1A3 | A | CAD | CARDIoGRAM | 3.4E-06 | 9.2E-04 | 2.2E-03 |
| rs5763662 | 22 | 30378703 | MTMR3 | T | TC | GLGC | 3.6E-05 | 1.5E-02 | 3.5E-02 |
| rs881803 | 16 | 15802334 | MYH11 | T | CAD | CARDIoGRAM | 5.5E-05 | 2.1E-02 | 4.7E-02 |
| rs4687614 | 3 | 52492085 | NISCH | A | WHR_BMI | GIANT | 2.0E-07 | 3.3E-04 | 1.5E-04 |
| rs360399 | 3 | 171362977 | PLD1 | A | HbA1c | MAGIC | 8.2E-06 | 2.2E-02 | 6.8E-03 |
| rs1265151 | 8 | 103213460 | RRM2B | A | CAD | CARDIoGRAM | 3.2E-05 | 1.5E-02 | 2.6E-02 |
| rs13332660 | 16 | 29905882 | SEZ6L2 | T | TC | GLGC | 1.5E-05 | 9.4E-03 | 1.4E-02 |
| rs13107325 | 4 | 103188709 | SLC39A8 | T | BMI | GIANT | 1.4E-07 | 5.4E-04 | 7.8E-05 |
| rs13107325 | 4 | 103188709 | SLC39A8 | T | HDL | GLGC | 7.2E-11 | 6.6E-08 | 7.1E-08 |
| rs9939417 | 16 | 31053467 | STX4 | T | TG | GLGC | 2.7E-07 | 1.5E-03 | 2.7E-04 |
| rs594522* | 6 | 152581079 | SYNE1 | A | TG | GLGC | 4.3E-05 | 4.0E-02 | 2.8E-02 |
| rs17611937 | 7 | 27775894 | TAX1BP1 | T | CAD | CARDIoGRAM | 3.0E-05 | 1.E-02 | 2.5E-02 |
| rs2655260 | 3 | 12563640 | TSEN2 | T | LDL | GLGC | 7.3E-06 | 8.8E-03 | 7.3E-03 |
| rs1618545 | 3 | 12560763 | TSEN2 | A | TC | GLGC | 1.3E-06 | 9.4E-03 | 1.3E-03 |
Adjusted P values are corrected for multiple testing. HDL = high density lipoprotein, Fasting Glu = fasting glucose, T2DM = type 2 diabetes mellitus, BMI = body mass index, CAD = coronary artery disease, TG = triglycerides, FDR = false discovery rate.
*
Also present in post-LPS PBMCs