Table 1. Approximate half-lives of antidepressants.

Antidepressant	Approximate half-life (days)
citalopram	1.5
escitalopram	1.5
paroxetine	1.0
sertraline	1.1–1.3
fluoxetine	4–16*
fluvoxamine	0.6
vortioxetine	2.4–2.8
agomelatine	0.04–0.08
desvenlafaxine	0.4
duloxetine	0.5
venlafaxine	0.6†
mianserin	0.9–2.5
mirtazepine	0.8–1.6‡
reboxetine	0.5
amitriptyline	0.2–1.9
imipramine	0.2–1.3
nortriptyline	0.8–2.3
doxepin	0.4–1.0
dothiepin	2.1
trimipramine	0.6–1.6
clomipramine	0.6–2.5
moclobemide	0.08
phenelzine	see below§
tranylcypromine	see below§

_* fluoxetine plus active metabolite norfluoxetine

† venlafaxine plus active metabolite desvenlafaxine

‡ a longer half-life (up to 65 hours) has occasionally been recorded and a shorter half-life is sometimes seen in young men

^§ biological activity persists for 14–21 days