Table 1. Associations of baseline cognitive domain composite and MMSE scores with seropositivity for antibodies to infectious agents.
| Infectious agent and proportion of individuals exposed1 | CMV | HSV-1 | HSV-2 | TOX |
|---|---|---|---|---|
| 83% | 78% | 10% | 48% | |
| Cognitive domains: | β (P value)2 | β (P value)2 | β (P value)2 | β (P value)2 |
| Attention | 0.0754 (NS) |
0.0613 (NS) |
-0.1745 (0.017) |
-0.0046 (NS) |
| Executive function | 0.0314 (NS) |
-0.0193 (NS) |
-0.2017 (0.003) |
-0.0766 (NS) |
| Memory | -0.0217 (NS) |
-0.0936 (NS) |
-0.2264 (0.002) |
-0.0706 (NS) |
| Language | 0.0161 (NS) |
-0.0575 (NS) |
-0.3046 (<0.001) |
-0.0465 (NS) |
| Visuospatial function | 0.0327 (NS) |
-0.0147 (NS) |
-0.4153 (<0.001) |
-0.1033 (NS) |
| MMSE | -0.0809 (NS) |
0.0852 (NS) |
-0.6047 (0.006) |
-0.0816 (NS) |
1
The proportion of individuals exposed to each infections agent was estimated using pre-determined cutoffs in antibody levels, see Methods.
2
β coefficients (P values) derived from separate regression analyses for each infectious agent, with individual cognitive domains as outcomes and seropositivity to infectious agents as predictors, adjusted for age, gender and educational status.
CMV: Cytomegalovirus, HSV-1: Herpes Simplex virus, type 1; HSV-2: Herpes Simplex virus, type 2; TOX: Toxoplasma gondii; MMSE: Mini Mental State Examination; NS: not significant.