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. 2016 Feb 5;62(3):225–234. doi: 10.1262/jrd.2015-167

Fig. 2.

Fig. 2.

miRNAs involved in the regulation of cell cycle checkpoint genes at G0, S, G2, and M phases. a) miRNAs involved in the regulation of cell cycle checkpoint genes at the G1/S transition. b) miRNAs involved in the regulation of cell cycle checkpoint genes at G0/G1 and S/G2 transitions. c) miRNAs involved in the regulation of cell cycle checkpoint genes at G2/M and M/G1 transitions. Main cycles of checkpoint, including G1 (first gap phase), S (synthesis phase), G2 (second gap phase), M (mitosis), and G0 are shown. Cell cycle regulators and effectors, which regulate and/or are regulated by miRNAs expressed in preimplantation embryo development, are grouped according to the cell cycle phase. Positive and negative relationship between miRNAs and mRNAs are shown according to the cell cycle: a) miRNAs involved in the regulation of cell cycle checkpoint genes at G1/S transition. b) miRNAs involved in the regulation of cell cycle checkpoint genes at the G0/G1 and S/G2 transitions c) miRNAs involved in the regulation of cell cycle checkpoint genes at the G2/M and M/G1 transitions [75, 80, 93, 95, 97, 118,119,120,121,122,123,124,125,126].