Fig. 4.

Schematic diagram of base excision repair pathway with genes and miRNAs regulating these genes. Genes involved in base excision repair and miRNAs predicted to regulate these genes are shown (http://www.microrna.org/microrna/home.do, http://www.targetscan.org/, http://mirdb.org/miRDB/). Several miRNAs were shown to target PARP1, which interacts with several genes involved in base excision repair and genes functioning at later stages of the base excision repair pathway. Bioinformatics studies also showed that PCNA is regulated by two miRNAs. Although a direct relationship among miRNAs and base excision repair genes, proteins, and polymerases has not been established, base excision repair components may be indirectly regulated by miRNA-regulated PARP1.