TABLE 5.
Comparison of WT and hmgcr knock-in mice subjected to lovastatin feeding
6–7-week-old male mice (4/group) were fed a chow diet in the absence or presence of 0.2% lovastatin for 5 days before study. WT mice were littermates of hmgcrWT/Ki and hmgcrKi/Ki mice. Each value represents the mean ± S.E. of four values.
| Parameter | WT (chow) | WT (0.2% lovastatin) | hmgcrKi/Ki (chow) | hmgcrKi/Ki (0.2% lovastatin) |
|---|---|---|---|---|
| Body weight (g) | 20.2 ± 0.7 | 20.5 ± 0.8 | 20.4 ± 1.1 | 20.1 ± 0.3 |
| Liver weight (g) | 1.16 ± 0.01 | 1.19 ± 0.04 | 1.33 ± 0.04 | 1.11 ± 0.03 |
| Plasma triglycerides (mg/dl) | 135 ± 18 | 142 ± 11 | 140 ± 8 | 209 ± 34 |
| Plasma cholesterol (mg/dl) | 99 ± 3 | 71 ± 5 | 115 ± 6 | 84 ± 12 |
| Plasma fatty acids (meq/liter) | 1.04 ± 0.02 | 1.10 ± 0.14 | 1.08 ± 0.09 | 1.75 ± 0.61 |
| Liver triglycerides (mg/g) | 5.6 ± 1.1 | 4.6 ± 0.4 | 7.1 ± 1.1 | 5.5 ± 0.7 |
| Liver cholesterol (mg/g) | 2.0 ± 0.2 | 2.0 ± 0.2 | 2.2 ± 0.1 | 2.2 ± 0.2 |