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Graphical overview of the functional consequences of mutation of the divergent residues in the PR domain between PRDM7 and PRDM9. All kcatapp values in Table 1 have been normalized to trimethylation of H3K4me2 by wild-type PRDM7 as 100, and represented in this figure. PRDM9 data are adapted from the work of Eram and colleagues (14).
