Figure 2.

The structure of the nSH3:PRM⁷⁵⁸ complex. (A) Representation of the 2Fo-Fc electron density map of PRM⁷⁵⁸ contoured at 1σ. The amino-acid sequence of PRM⁷⁵⁸ is shown at the bottom. Salt-bridges between K_-3 of PRM⁷⁵⁸ and three acidic residues (D147, E149, and D150) of the nSH3 domain are shown in red. Salt-bridges between the acidic residues in nSH3 domain and K^-3 of PRM⁷⁵⁸ are shown as dashed lines. Overlaid structures of (B) two nSH3 domains (gray and orange for molecules A and B in the PDB file, respectively) and (C) bound PRMs in an asymmetric unit of the nSH3:PRM⁷⁵⁸ complex crystal. PRMs bound to molecules A and B are shown in cyan and orange color, respectively. To see this figure in color, go online.