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Physiological effects of PsTag600‐FGF21 in lean mice. (A) In a 30 day pharmacological study, body weight was monitored throughout the treatment and recovery period. (B) Fed glucose. (C) Fasting glucose. (D) For OGTT, blood glucose was measured at 0, 15, 30, 60, 90 and 120 min. (E) Plasma insulin, leptin and non‐esterified fatty acid (NEFA) levels. (F) Body composition analyzed after 14 days of treatment. Data are means ± SD; n = 6 per group. * P < 0.05 versus vehicle‐treated SD mice.
