Skip to main content
. 2016 Jun 12;173(14):2278–2289. doi: 10.1111/bph.13510

Figure 1.

Figure 1

Serum and urinary phosphate (Pi) and Ca in normal rats on a high‐Pi diet. Male SD rats on a high‐Pi diet were treated with vehicle, VS‐505 or sevelamer (Renagel: sevelamer hydrochloride, and Renvela: sevelamer carbonate) in food (concentrations as indicated) for 5 days as described in the ‘Methods’ section. At two different time points (pre‐dosing and on day 5 after dosing), blood and urine samples were collected for Pi and Ca determination as described in the ‘Methods’ section. Mean ± SEM was calculated for each group (n per group as described in the ‘Methods’ section). The final number of rats per group was as follows: high‐Pi food alone, n = 11; 1% vehicle, n = 5; sevelamer HCl at 0.2, 1, 5 and 10%, n = 8, 8, 4, 6 respectively; VS‐505 at 0.04, 0.2, 1 and 5%, n = 6, 6, 9, 6 respectively; and sevelamer carbonate at 0.04, 0.2 and 1%, n = 5, 4, 4 respectively. (A) Serum Pi. (B) Urinary Pi in 24 h. (C) Serum Ca. (D) Urinary Ca in 24 h. One‐way ANOVA followed by Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons. # P < 0.05, ## P < 0.01, ### P < 0.001 versus pre‐dosing. *P < 0.05, **P < 0.01, ***P < 0.001 versus high‐Pi food alone.