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. 2016 Jun 12;173(14):2278–2289. doi: 10.1111/bph.13510

Figure 3.

Figure 3

Serum and urinary phosphate (Pi) and Ca in 5/6 NX rats on a high‐Pi diet. NX rats were treated with vehicle (Veh, at 1 or 5%), VS‐505 or sevelamer carbonate (concentrations at 0.2, 1 or 5%) in food for 4 weeks. Sham rats on high‐Pi diet with no addition of Veh or binders served as control. At three different time points (pre‐dosing, at week 2 post‐dosing and at week 4 post‐dosing), blood and urine samples were collected for Pi or Ca determination as described in the ‘Methods’ section. Mean ± SEM was calculated for each group (n per group as described in the ‘Methods’ section). The final number of rats per group is shown in Table 1. (A) Serum Pi. (B) Urinary Pi in 24 h. (C) Serum Ca. (D) Urinary Ca in 24 h. One‐way ANOVA followed by Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons. *P < 0.05, ***P < 0.001 versus pre‐dosing, the same group. # P < 0.05, ## P < 0.01, ### P < 0.001 versus sham, the same time point. Open bar: pre‐dosing. Solid bar: week 2 post‐dosing. Pattern bar: week 4 post‐dosing.