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. 2016 Jun 12;173(14):2278–2289. doi: 10.1111/bph.13510

Figure 6.

Figure 6

Serum PTH and FGF‐23 in 5/6 NX rats on a high‐Pi diet. NX rats were treated with vehicle (Veh), VS‐505 or sevelamer carbonate (5% in food) for 4 weeks as described in the ‘Methods’ section and in Figure 3. Sham rats on a high‐Pi diet with no addition of Veh or binders served as control. Serum samples were collected for PTH and FGF‐23 determination as described in the ‘Methods’ section. Mean ± SEM was calculated for each group. The final number of rats per group was as described in Table 1. (A) Serum FGF‐23. (B) Serum PTH. Statistical comparisons between two groups were performed by unpaired t‐test with 95% confidence intervals of difference. # P < 0.05, ## P < 0.01 versus pre‐dosing, the same group. *P < 0.05, **P < 0.01, ***P < 0.001 versus sham, pre‐dosing. Open bar: pre‐dosing. Solid bar: week 4 post‐dosing.