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. 2016 Jun 12;173(14):2278–2289. doi: 10.1111/bph.13510

Figure 8.

Figure 8

In vitro studies. (A) VS‐505 at 0.1 g was incubated with 10 mL of a 100 mM Pi solution (6.85 mL of 85% phosphoric acid, 3.18 g of sodium carbonate and 4.68 g of NaCl in 1 L of water) at 37°C at different values of pH (as indicated) for 24 h. The samples were processed for Pi determination as described in the ‘Methods’ section. Each point was triplicated, and the graph is representative of three independent experiments. (B) VS‐505 or sevelamer carbonate at 0.1 g was incubated with 10 mL of a Pi solution containing different concentrations of Pi (different amounts of 85% phosphoric acid, 3.18 g of sodium carbonate and 4.68 g of NaCl in 1 L of water) at neutral pH for 24 h at 37°C. Each point was triplicated, and the graph is representative of two independent experiments. (C) VS‐505 or sevelamer carbonate at 0.1 g (dry powder, time 0) was incubated with 5 mL of simulated gastric fluid [0.2% (w v‐1) NaCls, 0.7% (v v‐1) HCl, without pepsin] at 37°C for 5 h. The picture is representative of three independent experiments.