Table 1.

Serum BUN and creatinine in 5/6 nephrectomized uremic rats

	Serum BUN (mg·L−1)			Serum creatinine (mg·L−1)
Parameters	Pre‐dosing	Week 2	Week 4	Pre‐dosing	Week 2	Week 4
Sham	198.4 ± 9.6	178.2 ± 7.1	195.8 ± 7.9	3.7 ± 0.2	4.1 ± 0.6	3.5 ± 0.1
NX‐1% vehicle	374.3 ± 26.0#	386.1 ± 30.3#	416.8 ± 50.3*	8.5 ± 1.1*	10.6 ± 1.0*	9.3 ± 1.5*
NX‐5% vehicle	333.2 ± 28.9#	299.3 ± 21.3	298.1 ± 43.7	10.4 ± 0.9*	7.4 ± 0.7#	9.9 ± 0.5*
0.2% Renvela	415.7 ± 30.2*	438.9 ± 47.9*	428.4 ± 66.7*	7.7 ± 1.1#	7.8 ± 0.5#	8.5 ± 1.8*
1% Renvela	485.0 ± 19.9*	424.3 ± 14.9*	498.9 ± 28.8*	7.7 ± 0.4*	8.5 ± 0.2*	9.1 ± 1.0*
5% Renvela	413.8 ± 16.8*	388.7 ± 22.7*	407.5 ± 32.4*	9.4 ± 0.3*	10.3 ± 0.4*	10.2 ± 1.3*
0.2% VS‐505	336.9 ± 32.0 †	317.0 ± 30.9	336.0 ± 22.4	8.4 ± 0.5*	9.1 ± 0.6*	10.3 ± 1.0*
1% VS‐505	356.9 ± 16.7 †	371.8 ± 20.9#	365.1 ± 23.4 †	8.8 ± 0.6*	9.9 ± 0.6*	10.5 ± 0.8*
5% VS‐505	340.0 ± 22.0#	358.6 ± 28.2#	364.2 ± 44.0#	10.6 ± 0.5*	8.6 ± 0.7*	9.7 ± 0.3*

Note: Pre‐dosing: week 6 after surgery. Week 2: week 8 after surgery with 2 weeks of dosing. Week 4: week 10 after surgery with 4 weeks of dosing. Sham rats were on a high‐Pi diet with no addition of vehicle or binders. Data are shown as mean ± SEM. The final number of rats per group was as follows: sham, n = 9; 1% vehicle, n = 6; 5% vehicle, n = 9; sevelamer carbonate at 0.2, 1 and 5%, n = 7, 7, 8 respectively; and VS‐505 at 0.2, 1 and 5%, n = 8, 7, 13 respectively. One‐way ANOVA followed by Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons.

^* P < 0.001.

^# P < 0.01.

^† P < 0.05 versus sham, pre‐dosing.