Figure 4.

Upper panel: concentration–response curves for TFLLR‐NH₂‐induced contractions of bladder strips in vitro. Effect of pretreatment with F16357 or vehicle (DMSO 0.3%). Physiological conditions, n = 5 for all concentrations of F16357 and n = 7 for vehicle group (A). Pathological conditions, 24 h after CYP injection, n = 6 for all concentrations of F16357 and n = 10 for vehicle group (B). Lower panel: effect of pretreatment with F16357 or vehicle (DMSO 0.3%) on thrombin 3 U·mL⁻¹ incubation followed by TFLLR‐NH₂ 100 μM‐induced contraction of bladder strips in vitro. Physiological conditions, n = 5 for all groups (C). Pathological conditions, 24 h after CYP injection, n = 6 for vehicle group and n = 5 for F16357 group (D).