Fig. 3.

Metabolic phenotypes of Skn-1 KO mice fed a HFD.

(a) Changes in body weight under HFD conditions. When fed a HFD for 12 weeks after 4 weeks of age, Skn-1 KO mice exhibited dramatically reduced body weight compared with their WT littermates (n > 54).

(b) Skn-1 KO mice had a lower body fat percentage than their WT littermates, whereas there were no significant differences in muscle mass percentage between the two genotypes (n = 18–26).

(c) Skn-1 KO mice had lower tissue weights of epididymal and perirenal WAT (n = 6–12).

(d) Skn-1 KO and WT littermates had similar food intake at 8 weeks of age (n = 8–10).

(e) Skn-1 KO mice exhibited increased energy expenditure compared with their WT littermates (n = 4). The data are presented as the mean ± SEM; **p < 0.01 and *p < 0.05. See also Fig. S3.