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Capsids of HIV-1 variants resistant to MxB inhibition still interact with MxB. (A) Schematic of MxB-viral core binding assay: HIV-1 viruses were exposed briefly to 0.1% Triton X-100, mixed with soluble MxB containing cell lysates and subsequently loaded onto step sucrose gradients. (B) and (C) The individual gradient fractions representing soluble MxB (F1) and core-associated MxB (F3) were subjected to immunoblot analysis. Antibodies against HIV-1 CAp24 and MAp17 were used as controls.
