Table 3. Genotype distributions of the eleven SNPs among the cases and controls.
| Gene | SNPs | Control (n = 1526) n(%) | Total cases(n = 1601) | Smear-positive cases (n = 1080) | ||||
|---|---|---|---|---|---|---|---|---|
| n(%) | OR(95%Cl)a | P | n(%) | OR(95%Cl)a | P | |||
| IL-17A | rs2275913 | |||||||
| GG | 450(29.6) | 477(31.7) | 1 | 309(30.7) | 1 | |||
| GA | 741(48.7) | 729(48.4) | 0.89(0.75–1.06) | 0.192 | 494(49.2) | 0.94(0.77–1.13) | 0.500 | |
| AA | 331(21.7) | 301(20.0) | 0.79(0.64–0.97) | 0.028 | 202(20.1) | 0.82(0.65–1.04) | 0.098 | |
| Add | 0.89(0.80–0.99) | 0.027 | 0.91(0.81–1.02) | 0.106 | ||||
| Dom | 0.86(0.73–1.01) | 0.066 | 0.90(0.75–1.08) | 0.249 | ||||
| Rec | 0.85(0.71–1.02) | 0.074 | 0.85(0.70–1.05) | 0.129 | ||||
| G | 1641(53.9) | 1683(55.8) | 1 | 1112(55.3) | 1 | |||
| A | 1403(46.1) | 1331(44.2) | 0.93(0.84–1.02) | 0.131 | 898(44.7) | 0.95(0.84–1.06) | 0.323 | |
| rs3819024 | ||||||||
| AA | 422(27.7) | 442(28.2) | 1 | 284(26.8) | 1 | |||
| AG | 745(48.9) | 784(50.0) | 0.98(0.83–1.16) | 0.816 | 544(51.4) | 1.06(0.88–1.29) | 0.547 | |
| GG | 358(23.5) | 341(21.8) | 0.85(0.69–1.04) | 0.110 | 230(21.7) | 0.90(0.71–1.13) | 0.355 | |
| Add | 0.92(0.83–1.02) | 0.124 | 0.95(0.85–1.07) | 0.401 | ||||
| Dom | 0.94(0.80–1.10) | 0.421 | 1.01(0.84–1.21) | 0.942 | ||||
| Rec | 0.86(0.72–1.02) | 0.081 | 0.86(0.71–1.05) | 0.137 | ||||
| A | 1589(52.1) | 1668(53.2) | 1 | 1112(52.6) | 1 | |||
| G | 1461(47.9) | 1466(46.8) | 0.96(0.87–1.06) | 0.376 | 1004(47.4) | 0.98(0.88–1.10) | 0.748 | |
| rs8193036 | ||||||||
| CC | 783(51.4) | 789(51.1) | 1 | 515(49.7) | 1 | |||
| CT | 621(40.7) | 618(40.0) | 1.00(0.86–1.17) | 0.966 | 429(41.4) | 1.07(0.90–1.27) | 0.433 | |
| TT | 120(7.9) | 137(8.9) | 1.22(0.93–1.60) | 0.156 | 92(8.9) | 1.26(0.93–1.71) | 0.128 | |
| Add | 1.06(0.95–1.19) | 0.312 | 1.10(0.97–1.25) | 0.135 | ||||
| Dom | 1.04(0.90–1.20) | 0.623 | 1.10(0.94–1.30) | 0.246 | ||||
| Rec | 1.22(0.93–1.58) | 0.146 | 1.23(0.92–1.64) | 0.172 | ||||
| C | 2187(71.8) | 2196(71.1) | 1 | 1459(70.4) | 1 | |||
| T | 861(28.2) | 892(28.9) | 1.03(0.92–1.15) | 0.580 | 613(29.6) | 1.07(0.94–1.21) | 0.300 | |
| rs3748067 | ||||||||
| GG | 1094(71.8) | 1135(71.2) | 1 | 757(70.5) | 1 | |||
| GA | 385(25.3) | 415(26.1) | 1.06(0.89–1.25) | 0.528 | 286(26.6) | 1.09(0.90–1.31) | 0.369 | |
| AA | 45(3.0) | 43(2.7) | 1.02(0.66–1.58) | 0.935 | 31(2.9) | 1.13(0.70–1.83) | 0.607 | |
| Add | 1.04(0.90–1.19) | 0.592 | 1.08(0.93–1.26) | 0.325 | ||||
| Dom | 1.05(0.90–1.23) | 0.540 | 1.09(0.92–1.31) | 0.327 | ||||
| Rec | 1.00(0.65–1.55) | 0.984 | 1.11(0.69–1.79) | 0.670 | ||||
| G | 2573(84.4) | 2685(84.3) | 1 | 1800(83.8) | 1 | |||
| A | 475(15.6) | 501(15.7) | 1.01(0.88–1.16) | 0.878 | 348(16.2) | 1.05(0.90–1.22) | 0.549 | |
| IL-17F | rs763780 | |||||||
| TT | 1175(77.0) | 1225(77.6) | 1 | 840(79.0) | 1 | |||
| TC | 318(20.9) | 323(20.5) | 1.00(0.84–1.20) | 0.974 | 207(19.5) | 0.95(0.77–1.16) | 0.586 | |
| CC | 32(2.1) | 31(2.0) | 0.91(0.54–1.52) | 0.713 | 16(1.5) | 0.67(0.36–1.25) | 0.207 | |
| Add | 0.99(0.85–1.15) | 0.866 | 0.91(0.76–1.08) | 0.269 | ||||
| Dom | 0.99(0.84–1.18) | 0.947 | 0.92(0.76–1.12) | 0.397 | ||||
| Rec | 0.91(0.54–1.51) | 0.710 | 0.68(0.36–1.26) | 0.219 | ||||
| T | 2668(87.5) | 2773(87.8) | 1 | 1887(88.8) | 1 | |||
| C | 382(12.5) | 385(12.2) | 0.97(0.83–1.13) | 0.690 | 239(11.2) | 0.89(0.75–1.05) | 0.162 | |
| TLR4 | rs10759932 | |||||||
| TT | 779(51.4) | 722(45.7) | 1 | 505(47.2) | 1 | |||
| TC | 597(39.4) | 697(44.1) | 1.27(1.09–1.48) | 0.002b | 458(42.8) | 1.18(1.00–1.40) | 0.054 | |
| CC | 140(9.2) | 161(10.2) | 1.25(0.97–1.61) | 0.090 | 107(10.0) | 1.20(0.91–1.60) | 0.199 | |
| Add | 1.17(1.05–1.31) | 0.005 | 1.13(1.00–1.28) | 0.053 | ||||
| Dom | 1.27(1.09–1.46) | 0.001b | 1.19(1.01–1.39) | 0.037 | ||||
| Rec | 1.12(0.87–1.43) | 0.378 | 1.12(0.85–1.47) | 0.430 | ||||
| T | 2155(71.1) | 2141(67.8) | 1 | 1468(68.6) | 1 | |||
| C | 877(28.9) | 1019(32.2) | 1.17(1.05–1.30) | 0.005 | 672(31.4) | 1.13(1.00–1.27) | 0.055 | |
| rs2737190 | ||||||||
| AA | 557(37.0) | 518(32.6) | 1 | 343(32.0) | 1 | |||
| AG | 690(45.8) | 840(52.9) | 1.31(1.11–1.53) | 0.001b | 580(54.1) | 1.35(1.13–1.61) | 0.001b | |
| GG | 259(17.2) | 231(14.5) | 0.95(0.76–1.18) | 0.628 | 150(14.0) | 0.93(0.73–1.19) | 0.566 | |
| Add | 1.03(0.93–1.15) | 0.559 | 1.03(0.92–1.16) | 0.601 | ||||
| Dom | 1.21(1.04–1.41) | 0.015 | 1.23(1.04–1.46) | 0.015 | ||||
| Rec | 0.81(0.66–0.99) | 0.038 | 0.78(0.62–0.98) | 0.030 | ||||
| A | 1804(59.9) | 1876(59.0) | 1 | 1266(59.0) | 1 | |||
| G | 1208(40.1) | 1302(41.0) | 1.04(0.94–1.15) | 0.489 | 880(41.0) | 1.04(0.93–1.16) | 0.516 | |
| rs10983755 | ||||||||
| GG | 793(52.1) | 806(50.7) | 1 | 551(51.5) | 1 | |||
| GA | 600(39.4) | 644(40.5) | 1.06(0.91–1.23) | 0.450 | 424(39.6) | 1.02(0.86–1.21) | 0.829 | |
| AA | 128(8.4) | 139(8.7) | 1.06(0.81–1.38) | 0.672 | 95(8.9) | 1.07(0.80–1.44) | 0.636 | |
| Add | 1.04(0.93–1.17) | 0.472 | 1.03(0.91–1.17) | 0.650 | ||||
| Dom | 1.06(0.92–1.22) | 0.428 | 1.03(0.88–1.21) | 0.731 | ||||
| Rec | 1.03(0.80–1.34) | 0.808 | 1.07(0.80–1.42) | 0.665 | ||||
| G | 2186(71.9) | 2256(71.0) | 1 | 1526(71.3) | 1 | |||
| A | 856(28.1) | 922(29.0) | 1.04(0.94–1.17) | 0.446 | 614(28.7) | 1.03(0.91–1.16) | 0.664 | |
| rs7873784 | ||||||||
| GG | 1271(83.9) | 1310(83.1) | 1 | 876(82.2) | 1 | |||
| GC | 235(15.5) | 256(16.2) | 1.07(0.88–1.31) | 0.476 | 181(17.0) | 1.13(0.91–1.41) | 0.265 | |
| CC | 9(0.6) | 11(0.7) | 1.38(0.56–3.41) | 0.489 | 9(0.8) | 1.76(0.68–4.54) | 0.244 | |
| Add | 1.09(0.91–1.31) | 0.362 | 1.16(0.95–1.42) | 0.144 | ||||
| Dom | 1.09(0.89–1.32) | 0.411 | 1.15(0.93–1.43) | 0.192 | ||||
| Rec | 1.36(0.55–3.37) | 0.505 | 1.72(0.67–4.44) | 0.262 | ||||
| G | 2777(91.7) | 2876(91.2) | 1 | 1933(90.7) | 1 | |||
| C | 253(8.3) | 278(8.8) | 1.06(0.89–1.27) | 0.515 | 199(9.3) | 1.13(0.93–1.37) | 0.218 | |
| rs11536889 | ||||||||
| GG | 891(58.7) | 953(60.2) | 1 | 637(59.5) | 1 | |||
| GC | 545(35.9) | 535(33.8) | 0.95(0.81–1.11) | 0.506 | 372(34.7) | 0.99(0.83–1.18) | 0.911 | |
| CC | 83(5.5) | 94(5.9) | 1.04(0.76–1.43) | 0.799 | 62(5.8) | 1.03(0.72–1.47) | 0.859 | |
| Add | 0.98(0.87–1.11) | 0.780 | 1.00(0.88–1.15) | 0.970 | ||||
| Dom | 0.96(0.83–1.11) | 0.602 | 1.00(0.85–1.17) | 0.962 | ||||
| Rec | 1.06(0.78–1.45) | 0.704 | 1.04(0.73–1.47) | 0.840 | ||||
| G | 2327(76.6) | 2441(77.1) | 1 | 1646(76.8) | 1 | |||
| C | 711(23.4) | 723(22.9) | 0.97(0.86–1.09) | 0.606 | 496(23.2) | 0.99(0.87–1.12) | 0.836 | |
| miR-146a | rs2910164 | |||||||
| CC | 537(35.4) | 550(34.7) | 1 | 387(36.1) | 1 | |||
| CG | 715(47.2) | 775(48.9) | 1.08(0.92–1.27) | 0.360 | 505(47.2) | 1.01(0.84–1.21) | 0.927 | |
| GG | 264(17.4) | 259(16.4) | 0.96(0.77–1.19) | 0.691 | 179(16.7) | 0.94(0.74–1.19) | 0.620 | |
| Add | 1.00(0.90–1.10) | 0.934 | 0.98(0.87–1.10) | 0.693 | ||||
| Dom | 1.05(0.90–1.22) | 0.567 | 0.99(0.84–1.17) | 0.909 | ||||
| Rec | 0.92(0.76–1.11) | 0.378 | 0.94(0.76–1.16) | 0.554 | ||||
| C | 1789(59.0) | 1875(59.2) | 1 | 1279(59.7) | 1 | |||
| G | 1243(41.0) | 1293(40.8) | 0.99(0.90–1.10) | 0.884 | 863(40.3) | 0.97(0.87–1.09) | 0.610 | |
aOR: odds ratio; CI: confidence interval, adjusted for age, sex, smoking and drinking.
bSignificant after the Bonferroni correction for multiple comparisons. Add: additive model; Dom: dominant model; Rec: recessive model.