Table 5. The association analysis of genetic polymorphisms and treatment outcomes.
| Gene | SNP | Success (n%) | Failure (n%) | RR(95%Cl)a | P |
|---|---|---|---|---|---|
| IL-17A | rs2275913 | ||||
| GG | 397(30.9) | 23(43.4) | 1 | ||
| GA | 635(49.4) | 21(39.6) | 0.60(0.33–1.08) | 0.089 | |
| AA | 253(19.7) | 9(17.0) | 0.62(0.29–1.32) | 0.219 | |
| Add | 0.75(0.50–1.10) | 0.140 | |||
| Dom | 0.61(0.35–1.04) | 0.069 | |||
| Rec | 0.82(0.40–1.64) | 0.576 | |||
| rs3819024 | |||||
| AA | 376(28.1) | 23(41.1) | 1 | ||
| AG | 680(50.8) | 22(39.3) | 0.56(0.31–1.00) | 0.049 | |
| GG | 283(21.1) | 11(19.6) | 0.64(0.31–1.30) | 0.219 | |
| Add | 0.75(0.52–1.10) | 0.143 | |||
| Dom | 0.59(0.34–0.99) | 0.045 | |||
| Rec | 0.89(0.46–1.68) | 0.719 | |||
| rs8193036 | |||||
| CC | 675(51.3) | 23(42.6) | 1 | ||
| CT | 531(40.3) | 23(42.6) | 1.21(0.69–2.12) | 0.503 | |
| TT | 111(8.4) | 8(14.8) | 2.09(0.95–4.36) | 0.067 | |
| Add | 1.38(0.93–2.05) | 0.107 | |||
| Dom | 1.36(0.80–2.30) | 0.251 | |||
| Rec | 1.91(0.91–3.86) | 0.085 | |||
| rs3748067 | |||||
| GG | 971(71.9) | 38(66.7) | |||
| AG | 343(25.4) | 18(31.6) | 1.29(0.74–2.21) | 0.373 | |
| AA | 37(2.7) | 1(1.8) | 0.75(0.10–4.75) | 0.769 | |
| Add | 1.15(0.71–1.85) | 0.581 | |||
| Dom | 1.24(0.72–2.11) | 0.440 | |||
| Rec | 0.69(0.10–4.38) | 0.712 | |||
| IL-17F | rs763780 | ||||
| TT | 1056(78.6) | 37(66.1) | 1 | ||
| TC | 260(19.3) | 18(32.1) | 1.84(1.05–3.14) | 0.032 | |
| CC | 28(2.1) | 1(1.8) | 1.06(0.14–6.50) | 0.955 | |
| Add | 1.52(0.95–2.43) | 0.082 | |||
| Dom | 1.77(1.02–2.99) | 0.041 | |||
| Rec | 0.90(0.12–5.50) | 0.918 | |||
| TLR4 | rs10759932 | ||||
| TT | 622(46.2) | 23(41.1) | 1 | ||
| TC | 594(44.1) | 27(48.2) | 1.16(0.67–1.98) | 0.601 | |
| CC | 130(9.7) | 6(10.7) | 1.29(0.53–3.02) | 0.573 | |
| Add | 1.14(0.77–1.70) | 0.515 | |||
| Dom | 1.18(0.70–1.98) | 0.537 | |||
| Rec | 1.20(0.51–2.68) | 0.675 | |||
| rs2737190 | |||||
| AA | 452(33.6) | 18(32.1) | 1 | ||
| AG | 703(52.2) | 28(50.0) | 0.98(0.55–1.75) | 0.958 | |
| GG | 191(14.2) | 10(17.9) | 1.34(0.62–2.78) | 0.449 | |
| Add | 1.13(0.76–1.67) | 0.552 | |||
| Dom | 1.06(0.61–1.82) | 0.840 | |||
| Rec | 1.35(0.69–2.60) | 0.378 | |||
| rs10983755 | |||||
| GG | 682(50.7) | 26(45.6) | 1 | ||
| GA | 547(40.6) | 27(47.4) | 1.24(0.73–2.08) | 0.431 | |
| AA | 117(8.7) | 4(7.0) | 0.96(0.34–2.63) | 0.937 | |
| Add | 1.09(0.73–1.62) | 0.690 | |||
| Dom | 1.19(0.71–1.97) | 0.501 | |||
| Rec | 0.87(0.31–2.30) | 0.778 | |||
| rs7873784 | |||||
| GG | 1120(83.3) | 46(82.1) | 1 | ||
| GC | 215(16.0) | 9(16.1) | 1.03(0.51–2.06) | 0.924 | |
| CC | 9(0.7) | 1(1.8) | 2.61(0.35–12.18) | 0.337 | |
| Add | 1.16(0.62–2.17) | 0.643 | |||
| Dom | 1.10(0.56–2.13) | 0.780 | |||
| Rec | 2.60(0.35–12.17) | 0.339 | |||
| rs11536889 | |||||
| GG | 811(60.3) | 31(55.4) | 1 | ||
| GC | 453(33.7) | 23(41.1) | 1.31(0.77–2.21) | 0.312 | |
| CC | 81(6.0) | 2(3.6) | 0.66(0.16–2.63) | 0.568 | |
| Add | 1.07(0.70–1.64) | 0.753 | |||
| Dom | 1.22(0.72–2.03) | 0.453 | |||
| Rec | 0.60(0.14–2.32) | 0.464 | |||
| miR-146a | rs2910164 | ||||
| CC | 468(34.9) | 20(35.7) | 1 | ||
| GC | 660(49.3) | 25(44.6) | 0.91(0.51–1.60) | 0.737 | |
| GG | 212(15.8) | 11(19.6) | 1.18(0.57–2.38) | 0.645 | |
| Add | 1.06(0.73–1.54) | 0.766 | |||
| Dom | 0.98(0.57–1.66) | 0.930 | |||
| Rec | 1.25(0.65–2.36) | 0.495 |
aRR: rate ratio; CI: confidence interval, adjusted for age and sex.