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. 2016 Jun 24;6:28617. doi: 10.1038/srep28617

Figure 5. RBP-J-deficient macrophages exhibited a weakened pro-angiogenic phenotype.

Figure 5

(A) BMDMs were prepared from RBP-J cKO and control mice, and stimulated with PBS (N.C), LPS+IFN-γ (M1) or IL-4 (M2). The expression of iNOS, TNF-α, IL-β, IL-6, VEGF, Arg1, MR and IL-10 mRNA was determined by using qRT-PCR. (B) Culture supernatants of cells in (A) were collected, and the levels of TNF-α, IL-10, IL-1β, IL-6 and VEGF were determined by using ELISA. Each individual experiment was repeated at least three times. Data are presented as mean ± SEM from three mice per group. *P < 0.05, **P < 0.01, ***P < 0.001. NS, no significance.