Table 2. The odds ratio analysis of associated HTRA1 polymorphisms.
| Polymorphism | db SNP ID | Genotypic frequency |
AMD |
PCV |
AMD-PCV |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMD (n = 195) | PCV (n = 188) | Control (n = 183) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | ||
| −625G>A | rs11200638 | 109/63/23 | 70/84/33 | 38/90/55 | 1.16 × 10−5 | 3.21 (1.88–5.50) | 0.005 | 2.01 (1.23–3.28) | 0.106 | 1.60 (0.90–2.85) |
| −487T>C | rs2672598 | 162/31/2 | 109/67/10 | 97/68/18 | 1.31 × 10−4 | 10.53 (2.41–46.04) | 0.106 | 1.92 (0.86–4.28) | 0.015 | 5.48 (1.19–25.37) |
| c.34delCinsTCCT | – | 0/2/193 | 0/6/182 | 0/16/167 | 0.001 | 0.13 (0.03–0.57) | 0.029 | 0.34 (0.13–0.90) | 0.220 | 0.38 (0.08–1.89) |
| c.59C>T | – | 3/42/150 | 3/31/153 | 2/56/125 | 0.130 | 0.69 (0.43–1.11) | 0.004 | 0.49 (0.30–0.79) | 0.190 | 1.42 (0.84–2.31) |
| c.102C>T | rs1049331 | 108/64/23 | 70/81/34 | 38/90/55 | 1.16 × 10−5 | 3.21 (1.88–5.50) | 0.009 | 1.91 (1.17–3.11) | 0.072 | 1.68 (0.95–2.99) |
| c.108G>T | rs2293870 | 108/64/23 | 70/81/34 | 38/90/55 | 1.16 × 10−5 | 3.21 (1.88–5.50) | 0.009 | 1.91 (1.17–3.11) | 0.072 | 1.68 (0.95–2.99) |
The genotypic distribution was presented as homozygous/heterozygous/wild type. The odds ratios were assessed under dominant model.