Table 3. Haplotype-based association analysis of HTRA1 polymorphisms.
| Haplotypes | AMD vs Control |
PCV vs Control |
AMD vs PCV |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Ratio | p | OR (95% C.I.) | Ratio | p | OR (95% C.I.) | Ratio | p | OR (95% C.I.) | |
| ACCTT | 0.718:0.451 | <0.0001 | 3.10 (2.29–4.19) | 0.577:0.450 | 0.0007 | 1.66 (1.24–2.22) | 0.718:0.578 | <0.0001 | 1.87 (1.38–2.52) |
| GTCCG | 0.090:0.284 | <0.0001 | 0.25 (0.16–0.38) | 0.219:0.283 | 0.0128 | 0.71 (0.51–1.00) | 0.089:0.217 | <0.0001 | 0.35 (0.23–0.54) |
| GCTCG | 0.121:0.164 | 0.1677 | 0.70 (0.46–1.06) | 0.100:0.163 | 0.0500 | 0.57 (0.37–0.89) | 0.120:0.100 | 1.0000 | 1.22 (0.78–1.92) |
| GCCCG | 0.069:0.096 | 0.3826 | 0.70 (0.42–1.19) | 0.081:0.098 | 0.1232 | 0.65 (0.38–1.11) | 0.070:0.066 | 1.0000 | 1.04 (0.59–1.84) |
The haplotypes were defined by rs11200638, rs2672598, c.59C>T, rs1049331 and rs2293870. The p-value was corrected by permutation test (n = 10,000).