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. Author manuscript; available in PMC: 2016 Jun 24.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2016;56:605–626. doi: 10.1146/annurev-pharmtox-010715-103209

Figure 1.

Figure 1

Major kinds of liver diseases discussed in this review: nonalcoholic fatty liver disease, liver inflammation and fibrosis, viral hepatitis infections, cholestatic liver disease, hepatocellular cancer, and drug-induced liver injury. Nuclear receptors are grouped separately based on their regulatory role in diseases: those for which activation alleviates disease (blue) and those for which activation exacerbates disease (red ). Abbreviations: CAR, constitutive androstane receptor; FXR, farnesoid X receptor; GR, glucocorticoid receptor; HNF4α, hepatocyte nuclear factor-4-alpha; LRH, liver-related homolog; LXR, liver X receptor; PPAR, peroxisomal proliferate activating receptor; PXR, pregnane X receptor; RXR, retinoid X receptor; SHP, small heterodimer partner; VDR, vitamin D receptor.