Table 1.

Multivariable analysis of prognostic factors for overall and disease-free survival

		Overall survival			Disease-free survival
Multivariable analysis		HR	95%CI	P	HR	95% CI	P
Variables
AFP	> 400 ng/mL	1.145	0.543-2.418	0.722	1.003	0.556-1.811	0.991
PET/CT	Positive	2.652	1.384-5.085	0.003	2.517	1.481-4.279	0.001
Tumor number	> 3	0.647	0.294-1.425	0.280	0.814	0.425-1.557	0.534
Maximum tumor size	> 5 cm	0.696	0.307-1.580	0.386	1.551	0.836-2.877	0.164
Total tumor size	> 10 cm	2.909	1.230-6.880	0.015	3.003	1.536-5.870	0.001
Differentiation1	III-IV	1.206	0.616-2.358	0.585	1.010	0.594-1.717	0.972
Microvascular invasion	Present	1.269	0.522-3.084	0.599	2.148	1.064-4.336	0.033
Capsule formation	Present	0.439	0.166-1.162	0.097	0.737	0.353- 1.542	0.418
Major vessel invasion	Present	2.017	0.829-4.905	0.122	1.712	0.850-3.449	0.132
Ductal invasion	Present	0.907	0.265-3.100	0.876	1.409	0.534-3.720	0.489
Serosal invasion	Present	1.463	0.670-3.195	0.339	1.047	0.553-1.984	0.887
Intrahepatic metastasis	Present	1.471	0.595-3.640	0.404	1.519	0.752-3.070	0.244
Dysplastic nodule	Present	0.744	0.365-1.514	0.414	0.840	0.478-1.479	0.546

¹Edmondson-Steiner Grade. CT: Computed tomography; PET: Positronemission tomography; AFP: α-fetoprotein.