Table 3.

Indications of rFVIIa and plasma and PRBC (1:1 ratio)

	Clinical conditions
Bleeding not controlled	Truncal/axillary/neck or groin
with tourniquets or local haemostatic dressings (‘quickclot’)	bleeding
Proximal amputation or mangled extremity	Large soft tissue injuries
Chest tube drainage	> 1000 cc blood total
	> 200 cc/hr for 4 consecutive horns
Physical exam findings	Decreased mental status from injury and shock Severe head injury Clinically coagulopathic
Objective physical exam or	INR ≥ 1.5
Laboratory findings	BD ≥ 6
	Haemoglobin - < 11g/dL in young Hypothermic from blood loss (T<96°F)
	Hypotensive from blood loss (SBP < 90 mmHg) or a weak/absent radial pulse
Need for fresh whole blood	Bilateral proximal amputations
Transfusion	Large hemoperitoneum and significant shock
INR: International normalized ratio; BD: Base deficit