Fig. 2.

The positions of protein targeting motifs within genes and proteins are not uniformly distributed. a Most NLSs and NESs are entirely contained in only one exon. b Length distributions of NLSs and NESs. While NESs are represented by a unimodal length distribution, NLSs are characterized by a multimodal distribution, reflecting the diverse types of NLSs (monopartite, bipartite, PY-NLS) that have been described and that are considered in this study. c Distribution of the position of NLSs and NESs in proteins. d The majority of NLS and NES are regulated in an alternative manner