Fig. 4.

Examples of alternative NLSs and NESs regulated by alternative transcription/translation initiation or termination. Screenshots of UCSC Genome Browser as described in Fig. 3. a SMAD3 NLS regulated by alternative transcription and alternative initiation. b The MIER1 NES is encoded in a cassette exon and its inclusion is also regulated by alternative transcription and alternative initiation (some transcripts, highlighted in a pink box, start at a downstream exon). c The BIRC5 NES inclusion is regulated by alternative transcription and translation end (some transcripts end before the exon containing the targeting motif) and by a frameshift (visible in panel d, which represents a zoomed-in section of panel c)