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. 2016 Jun 24;17:472. doi: 10.1186/s12864-016-2854-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Number of motifs regulated by the different pre-translational regulation modes. Of the 175 NLSs considered, 68 are constitutive. The 107 alternatively regulated NLSs are classified with respect to 4 modes of regulation in panel a (left): direct alternative splicing of the encoding exon, differential translation initiation, differential translation termination and frameshift. Similarly, of the 120 NESs considered, 34 are constitutive and panel a (right) shows the regulation types of the 86 alternative NESs. Alternatively regulated NLSs and NESs are present in genes producing significantly more transcripts than constitutive NLSs and NESs as shown in b (NLS on the left panel and NES on the right)