Fig. 8.

Co-regulation of NLS and NES. 45 genes encoding both an NLS and NES were detected by RNA-seq in the Human Body Map project. The distribution of their regulation types are shown in panel a, with both motifs being constitutive or both being alternative as the most abundant groups. The distribution of motif inclusion for both the NLS and NES in a subset of these genes is shown in panel b. FOXO3 represents a gene with both constitutive NLS and constitutive NES. FHL1 represents the group of genes with co-regulated but alternative NLS and NES. MIER1 and RIPK3 have differentially regulated NLS and NES, with MIER1 showing high prevalence of NLS and low presence of NES while RIPK3 has a constitutive NES and an alternative and variably present NLS