TABLE 1.

Lessons learned from mouse models.

Key findings	Reference
First murine model of EoE. EoE induced by intratracheal administration of Aspergillus fumigatus.	Mishra 2001 [25]
EoE induced by intratracheal IL-13. Mechanism is dependent on IL-5, eotaxin-1, and STAT6.	Mishra 2003 [45]
Mice were sensitized epicutaneously to develop experimental EoE. First evidence that antigens could be sensitized via the skin in EoE.	Akei 2005 [26]
Mice deficient in the eotaxin-3 receptor (CCR3−/−) could not develop EoE.	Blanchard 2006 [13]
T-cells, but not B-cells, are required to trigger EoE.	Mishra 2007 [17]
IL-5-deficient mice or eosinophil-lineage deficient mice had significantly less tissue remodelling.	Mishra 2008 [82]
EoE was induced intranasally by cockroach and dust mite allergens in an eotaxin and IL-5 mediated pathway. Mice deficient in eotaxin-1/2, CCR3 or IL-5 failed to develop EoE.	Rayapudi 2010 [43]
Administration of anti-Siglec-F antibodies significantly decreased eosinophilic inflammation.	Rubinstein 2011 [28]
Mice were sensitized intraperitoneally, and then challenged intranasally or intragastrically with corn or peanut to induce EoE. Disease process is dependent on eotaxin and iNKT-cells.	Rajavelu 2012 [83]
IgE is not required to generate experimental EoE. EoE is TSLP and basophil dependent.	Noti 2013 [16]
Mast cell-deficient mice model had reduced hyperplasia and hypertrophy, but showed no difference on eosinophil recruitment to the oesophagus.	Niranjan 2013 [84]