Figure 3.
Branch formation in O-mannose glycans. GnT-IX acts on an O-mannose glycan after the action of PomGnT-I. Branched O-mannose glycan is expressed on a phosphatase, PTPRZ, and regulates remyelination in the brain. Phosphorylated and elongated O-mannose glycan is attached to α-dystroglycan, which is essential for muscle functions.
