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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Brain Res. 2016 Feb 2;1636:43–51. doi: 10.1016/j.brainres.2016.01.042

Figure 2.

Figure 2

Expression of P2Y1 receptors in DRG and spinal cord and effect of the selective P2Y1 receptor antagonist MRS2500 (MRS) in rats subjected to spared nerve injury (SNI). Time course of the withdrawal threshold observed after SNI (panel A). Expression of P2Y1 receptors in the ipsilateral (IL) dorsal root ganglia (DRG) and dorsal spinal cord (SC) in sham (S) and neuropathic rats at 1, 3, 7 and 14 days after injury (panels B, C and D). Antiallodynic effect of MRS2500 in rats previously (3 days) subjected to SNI (panel E). Effect of MRS2500 on SNI-induced up-regulation of P2Y1 receptors in DRG of rats previously (3 days) subjected to SNI (panel F). Antiallodynic effect of MRS2500 in rats previously (14 days) subjected to SNI (panel G). Effect of MRS2500 on SNI-induced up-regulation of P2Y1 receptors in DRG of rats previously (14 days) subjected to SNI (panel H). Behavioral and molecular data are expressed as mean ± S.E.M. for 6 and 3 animals, respectively. Data are expressed as the time course of the withdrawal threshold and 50% threshold withdrawal against time curve (AUC). * p < 0.05, ** p < 0.01 and *** p < 0.001, significantly different from the vehicle (Veh) or Sham (S) group, as determined by one (panels C and D) or two-way (panels E and G) analysis of variance followed by the Dunnett's test or Bonferroni test, respectively. +p < 0.05, ++ p<0.01 and +++ p<0.001, significantly different form the SNI + Veh group. Student t-test was used to compare 2 independent groups.