Table 1.
Gene(s) | Locus | Gene function | Affected phenotype | Reference |
---|---|---|---|---|
Substrate utilization & respiration | ||||
melA | lp_3485 | α‐Galactosidase | Melibiose utilization | Lambert et al. (2007) |
lacS2 | lp_3468 | Sugar permease | ND | Lambert et al. (2007) |
cydA | lp_1125 | Subunit cytochrome (bd type) | Oxidative respiration | Brooijmans et al. (2009) |
narG | lp_1497 | Subunit nitrate reductase | Nitrate respiration | Brooijmans et al. (2009) |
rpoN | lp_0787 | Sigma factor 54 | Global expression | Stevens et al. (2010) |
manR | lp_0585 | Mannose operon regulator | Mannose utilization | Stevens et al. (2010) |
manIIC | lp_0576 | Mannose transport | Mannose utilization | Stevens et al. (2010) |
ccpA | lp_2256 | Carbon control protein | Glucose repression | Zotta et al. (2012) |
lpdB | lp_0271 | Gallate decarboxylase | Tannine utilization | Jiménez et al. (2013) |
lpdC | lp_2945 | Gallate decarboxylase | Tannine utilization | Jiménez et al. (2013) |
Quorum sensing & bacteriocin production | ||||
lamA | lp_3580 | Response regulator | QS/EPS/biofilm production | Sturme et al. (2005) |
lamR | lp_3087 | Response regulator | QS/EPS/biofilm production | Fujii et al. (2008) |
plnGHSTUVWX | lp_0423‐0430 | QS pheromone & transport | QS pheromone production | Meijerink et al. (2010) |
plnEFI | lp_0419‐0423 | ABC transporter | Plantaricin transport | Meijerink et al. (2010) |
plnABCD | lp_0415‐0418 | Plantaricin & QS module | Plantaricin A production | Maldonado‐Barragán et al. (2009) |
Stress response and intestinal tract survival | ||||
bsh1 | lp_3538 | Choloyl glycin hydrolase | Bile resistance | Lambert et al. (2007) |
bsh2‐bsh3‐bsh4 | lp_0067‐lp_3362‐lp_2572 | Penicillin acylase | Acylase activity | Lambert et al. (2008a) |
ctsR | lp_1018 | Class III stressor | Stress/control ftsH expression | Fiocco et al. (2009) |
ftsH | lp_0547 | Chaperone protease | Stress resistance | Fiocco et al. (2009) |
hsp 18.55 | lp_3352 | Heat shock protein | Membrane fluidity | Capozzi et al. (2011) |
Cell surface proteins & host interaction | ||||
lp_0373 | lp_0373 | Cell Surface protein | ND | Pretzer et al. (2005) |
msa | lp_1229 | Mannose‐specific adhesion | Agglutination | Pretzer et al. (2005) |
srtA | lp_0514 | Sortase | Protein anchoring | Pretzer et al. (2005) |
lp_2940 | lp_2940 | Cell surface protein | Mouse GI tract passage | Bron et al. (2007) |
lp_1164 | lp_1164 | Cellobiose EII transporter | Mouse GI tract passage | Bron et al. (2007) |
lp_3055 | lp_3055 | Copper transporter | Mouse GI tract passage | Bron et al. (2007) |
napA3 | lp_2827 | Na/H antiporter | In vitro GI tract survival | Van Bokhorst‐van de Veen et al. (2012a) |
pbp2A | lp_1413 | Penicillin‐binding protein | In vitro GI tract survival | Van Bokhorst‐van de Veen et al. (2012a) |
lp_1699 | lp_1699 | AraC regulator | In vitro GI tract survival | Van Bokhorst‐van de Veen et al. (2012a) |
Cell shape or surface properties modulation | ||||
dltD | lp_2016 | D‐alanine transfer | Charged techoic acids | Grangette et al. (2005) |
alr | lp_0523 | Alanine racemase | Cell envelope integrity | Palumbo et al. (2004) |
acm2 | lp_2645 | N‐acetyl glucosaminidase | Autolysin cell separation | Rolain et al. (2012) |
lytA | lp_3421 | D,L endopeptidase | Cell shape and integrity | Rolain et al. (2012) |
lys2 | lp_3093 | N‐acetylmuramidase | Cell separation | Rolain et al. (2012) |
tagF1‐tagF2 | lp_0268‐ lp_0269 | Glycerol phosphate transferase | Wall techoic acid modification | Tomita et al. (2013) |
cps1A | lp_1177 | SPS production | Reduced SPS and rhamnose level | Remus et al. (2012) |
cps2A | lp_1197 | SPS production | Reduced SPS levels | Remus et al. (2012) |
cps3A‐cps4A | lp_1215‐ lp_2108 | SPS production | Reduced SPS levels | Remus et al. (2012) |
gtfA | lp_1299 | Glycosyl transferase | Surface protein glycosylation | Lee et al. (2014) |
gtfB | lp_1311 | Glycosyl transferase | Surface protein glycosylation | Lee et al. (2014) |
oatA | lp_0856 | O‐acetyl transferase | Cell septation | Bernard et al. (2011) |
oatB | lp_0925 | O‐acetyl transferase | Cell septation | Bernard et al. (2011) |
GI, Gastrointestinal; EPS, Extracellular polymeric substance; SPS, Surface Poly Saccharide; QS, Quorum Sensing; ND, not detected.