Table 2.

Clinical applications of circulating tumor DNA for non-Hodgkin lymphoma

	Pretreatment	Receiving treatment	End-of-treatment	After treatment
ctDNA of VDJ sequence	Prognostic tool	Quantitate tumor kinetics Early treatment failure Response-adapted therapy	Molecular remission Maintenance therapy decisions	Early recurrence detection Clonal evolution
Tumor genotypic ctDNA	Prognostic tool	Quantitate tumor kinetics	Molecular remission	Early recurrence detection
	Initial therapy choice	Early treatment failure Early resistance mechanisms Response-adapted therapy	Maintenance therapy decisions	Clonal evolution Late resistance mechanisms Select next therapy