Table 3.
Documented pathogens associated with STAT1 GOF mutations
| Associated pathogens | Documented infections (%) |
|---|---|
| Mucocutaneous fungal infections | n = 172 |
| Candida albicans | 140 (82) |
| Dermatophytes | 23 (13) |
| Others* | 9 (5) |
| Invasive fungal infections | n = 34 |
| Candida spp. | 10 (29) |
| Pneumocystis jirovecii | 6 (18) |
| Aspergillus spp. | 5 (15) |
| Cryptococcus spp. | 6 (18) |
| Others† | 7 (20) |
| Bacterial infections | n = 99 |
| Staphylococcus aureus | 36 (36) |
| Streptococcus spp. | 20 (20) |
| Pseudomonas aeruginosa | 13 (13) |
| Haemophilus influenzae | 9 (9) |
| Others‡ | 21 (21) |
| Mycobacterial infections | n = 17 |
| M tuberculosis | 6 (35) |
| BCG strain | 5 (30) |
| Others§ | 6 (35) |
| Viral infections|| | n = 162 |
| Herpes simplex | 44 (27) |
| Varicella-zoster | 51 (31) |
| Molluscum contagiosum/warts | 32 (12) |
| CMV or EBV | 25 (15) |
| Others¶ | 10 (6) |
| Parasitic infections# | n = 2 |
*
C glabrata, C tropicalis, C kefir, C membranifaciens, C famata, C dubliniensis, and Malassezia furfur.
†
Histoplasma, Trichosporon, Coccodioides, Apophysomyces.
‡
Enterobacteriaceae, Campylobacter spp., Stenotrophomonas maltophilia, anaerobic pathogens, Neisseria meningitidis.
§
M avium, M fortuitum, M mucogenicum, M genavense, or not identified.
||
Clinically probable or microbiologically confirmed.
¶
HHV6, adenovirus, parvovirus, BK virus, hepatitis C virus, live virus vaccine disease.
#
Giardiasis, visceral leishmaniasis.