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. 2016 Jun 24;6:28436. doi: 10.1038/srep28436

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Copyright © 2016, Macmillan Publishers Limited

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(A) AurkA overexpression in MCF-7 cells promoted AurkA protein stabilization and increased levels of β–catenin, Wnt3a, Stat3 and Mmp9 proteins; (B) conversely, AurkA knock-down dramatically reduced AurkA protein levels as well as levels of β–catenin, Wnt3a, Stat3 and Mmp9 proteins. β–actin is a loading control. (C) AurkA overexpression associated with a metastatic signature in MCF-AurkA cells as suggested by increased expression of CD44v6, Snail, Twist and c-Met and increased migratory activity (right graph) in comparison with control cells (empty). (D) In contrast, MDA-shAurkA cells lost that signature showing a repression of CD44v6, Snail and c-Met and a marked inhibition of migratory activity (right graph) in comparison with control cells (empty).